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Interaction of catechins with aluminum in vitro

Tea is one of the most popular beverages, consumed by over two thirds of the world"s population; but the aluminum accumulation property of tea plant is becoming the focus of many researches because of aluminum"s known adverse effect on human health. Investigation of the interactions of catechins with A1^3+ showed that during the interaction of catechins with A1^3+, the UV-vis spectrum of catechins was changed. Absorption of EGCG at 274 nm decreased and increased at 322 nm; EC and C"s at 278 nm changed little. The ratio of A1^3+ to EGCG was 1:1 in pH 5.0 buffer solution; in pH 6.2 buffer solution, the ratio in the A1-EGCG complex was 1:1. Interestingly, while the ratio reached to over 2, after the complex of A1-EGCG started polymerization, the ratio in the polymer was 2:1. In pH 6.2 buffer solution, the complex behavior of C with A1^3+ was the same as that of EGCG, with a little difference for EC. When the ratio of A1^3+ to EC was<1, the complex in ratio was 1:2, but, the complex polymerized when the ratio of A13+ to EC was >1. It was found that the ratio of A1^3+ to EC in the polymer was 1:1. Polymerization of A1-catechin complexes might reduce aluminum absorption in the intestine. Kow value was also employed to study the properties of aluminum species in tea infusion (at gastric and intestine pH condition) and the effect of catechins and tea polyphenols on Kow in buffer solution. Results showed that Kow value rose much higher at the intestine pH than at the gastric pH. Tea polyphenols and catechins could greatly reduce aluminum Kow value in acetic buffer,indicating that these compounds may reduce aluminum absorption during tea intake.

完成机构：[1]DepartmentofTeaSciences,ZhejiangUniversity,Hangzhou310029,China [2]ZhejiangHzsunPharmaceuticalCo.Ltd,Taizhou318000,China

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